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Limitations-of-use reserve fluoroquinolones for patients who do not have other available treatment options for acute sinusitis indicated for chronic bacterial prostatitis caused by escherichia coli or proteus mirabilis limitations-of-use reserve fluoroquinolones for patients who do not have other available treatment options for acute bacterial exacerbation of chronic bronchitis acute uncomplicated immediate-release, 250 mg po q12hr for 3 days extended-release, 500 mg po q24hr for 3 days limitations-of-use reserve fluoroquinolones for patients who do not have other available treatment options for uncomplicated urinary tract infections inhalation (prophylaxispostexposure) 500 mg po q12hr or 400 mg iv q12hr for 60 days dry powder for inhalation orphan designation for patients with ncfb who suffer from frequent severe acute pulmonary bacterial exacerbations which lead to further inflammation, airway, and lung parenchyma damage aeromonas hydrophila, bacillus anthracis, bacteroides fragilis, campylobacter jejuni, citrobacter freundii, citrobacter diversus, enterobacter cloacae, enterococcus faecalis, escherichia coli, haemophilus ducreyi, haemophilus influenzae, haemophilus parainfluenzae, klebsiella pneumoniae, legionella pneumophila, morganella morganii, moraxella catarrhalis, certain mycobacteria, neisseria gonorrhoeae, proteus mirabilis, providencia spp, pseudomonas aeruginosa, salmonella typhi, serratia spp, shigella spp, methicillin-sensitive staphylococcus aureus (mssa), staphylococcus epidermis, staphylococcus saprophyticus, streptococcus pneumoniae, vibrio cholerae, yersinia enterocolitica first-line therapy b anthracis, c freundii, c jejuni, enterobacter spp, hafnia alvei, s typhi, salmonella spp, shigella spp no unanimity on others (eg, k pneumoniae, m morganii, v cholerae, y enterocolitica ) 1 year (iv) 6-10 mgkgq8hr individual dose not to exceed400 mg for 10-21 days 1 year (po) 10-20 mgkgq12hr individual dose not to exceed 750 mg q12hr for 10-21 days indication for treatment and prophylaxis of plague due to yersinia pestis in pediatric patients from birth to 17 years of age change antibiotic to amoxicillin as soon as penicillin susceptibility confirmed acute generalized exanthematous pustulosis (agep), erythema multiforme, exfoliative dermatitis, fixed eruption, photosensitivityphototoxicity reaction agranulocytosis, albuminuria, serum cholesterol and tg elevations, blood glucose elevation, hemolytic anemia, marrow depression (life threatening), pancytopenia (life threatening or fatal outcome), potassium elevation (serum) anaphylactic reactions (including life-threatening anaphylactic shock), serum sickness like reaction, stevens-johnson syndrome constipation, dyspepsia, dysphagia, flatulence,hepatic failure (including fatal cases), hepatic necrosis, jaundice, pancreatitis hypertonia, hypotension (postural), increased inr (in patients treated with vitamin k antagonists), qt prolongation, torsade de pointes, ventricular arrhythmia myasthenia, exacerbation of myasthenia gravis, myoclonus, nystagmus, peripheral neuropathy that may be irreversible, phenytoin alteration (serum), polyneuropathy, psychosis myalgia, tendinitis, tendon rupture, toxic epidermal necrolysis (lyells syndrome), twitching infections candiduria, vaginal candidiasis, moniliasis (oral, gastrointestinal, vaginal), pseudomembranous colitis fluoroquinolones have been associated with disabling and potentially irreversible serious adverse reactions that have occurred together including tendinitis and tendon rupture, peripheral neuropathy, and central nervous system (cns) effects discontinue treatment immediately and avoid use of systemic fluoroquinolones in patients who experience any of these serious adverse reactions may exacerbate muscle weakness in patients with myasthenia gravis avoid fluoroquinolones with known history of myasthenia gravis because the risk of these serious side effects generally outweighs the benefits for patients with acute bacterial sinusitis, acute exacerbation of chronic bronchitis, and uncomplicated utis, that fluoroquinolones should be reserved for use in patients with these conditions who have no alternative treatment options use in pregnancy, though generally contraindicated for all quinolones, is allowed for life-threatening situations limited data from use of ciprofloxacin in pregnancy show no higher rate of birth defects than background do not use oral suspension in nasogastric tube to prepare, add microcapsules to diluent commonly seen adverse reactions include tendinitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and central nervous system effects (hallucinations, anxiety, depression, insomnia, severe headaches, and confusion) these reactions can occur within hours to weeks after starting therapy, including in patients of any age or without pre-existing risk factors discontinue therapy immediately at first signs or symptoms of any serious adverse reaction in addition, avoid use of fluoroquinolones, in patients who have experienced any serious adverse reactions associated with fluoroquinolones (see black box warnings) peripheral neuropathy sensory or sensorimotor axonal polyneuropathy affecting small andor large axons resulting in paresthesias, hypoesthesias, dysesthesias, and weakness reported peripheral neuropathy may occur rapidly after initiating and may potentially become permanent in prolonged therapy, perform periodic evaluations of organ system functions (eg, renal, hepatic, hematopoietic) adjust dose in renal impairment superinfections may occur with prolonged or repeated antibiotic therapy discontinue use immediately if signs and symptoms of hepatitis occur not first drug of choice in pediatrics (except in anthrax), because of increased incidence of adverse events in comparison with control subjects, including arthropathy no data exist on dosing for pediatric patients with renal impairment (ie, crcl)...

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